Some GPU configurations and/or GPU models are incompatible with Substance 3D Painter and will lead to instabilities and crashes. Below is a list of the incompatible configurations :

Configuration Solution

Nvidia SLI / AMD Crossfire
(Graphic card bridges)

Disable SLI or Crossfire in the GPU driver settings.
(Two GPU chipsets on one graphic card)
Disable the use of the two GPU chipsets in the drivers settings to only one.